ORCHARD PARK, N.Y. – A week ago, the Titans were flying high following a win over the defending Super Bowl champs.
On Sunday, Titans quarterback Marcus Mariota and the offense left here full of frustration following a mistake-filled day in a 13-12 loss to the Bills.
"We left one out there today," Mariota said. "We can't turn the ball over as an offense. The defense played great – they've played outstanding through the year. We have to do a better job of playing complimentary football.
"It is the nature of the beast, man. This is the business we play. If you are not ready to play, it doesn't matter who you are playing, you are not going to be able to put forth your best effort and (you) ultimately lose the game."
Mariota completed 14-of-26 passes for 129 yards, with an interception.
The Titans turned the ball over three times in the game.
Receiver Taywan Taylor and running back Dion Lewis lost fumbles that were recovered by the Bills.
The Titans also had a key drop by receiver Nick Williams in the fourth quarter.
Williams made no excuses after the game.
"Marcus made a great play keeping the play alive, scrambling," Williams said. "He threw a great pass -- that's all on me. One-hundred percent, that's pro ball. Quarterbacks throw it, receivers catch it. You have to make that play."
The Titans picked up just 221 yards in the contest, and 15 first downs. Receiver Corey Davis led the Titans with four catches for 49 yards, while receivers Tajae Sharpe and Taylor each had three catches for 30 yards.
The Titans managed 100 yards on the ground, with running back Derrick Henry leading the way with 56 yards.
"Just knowing we kind of beat ourselves from the beginning of the game – we kind of shot ourselves in the foot," Sharpe said. "This is the NFL – you can't take any games off. We came out and and started slow. It all falls on our shoulders, and we have to come in tomorrow and clean things up and get ready for next week."
While the Titans were 6-of-12 on third down, the team didn't take care of business in the red zone.
Kicker Ryan Succop provided all the points in the game.
"You can't kick field goals and think you are going to win the game," Mariota said. "We have to be better. We have to be a lot better."
The Tennessee Titans take on the Buffalo Bills in Week 5 of the 2018 season on Sunday, Oct. 7, 2018 at New Era Field. (Photos: Donn Jones, AP)
Tennessee Titans quarterback Marcus Mariota scrambles against the Buffalo Bills during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota scrambles against the Buffalo Bills during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota takes the first snap of the game during the first half of NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans kicker Ryan Succop (4) kick a field goal against the Buffalo Bills during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans wide receiver Taywan Taylor (13) runs with the ball as Buffalo Bills linebacker Tremaine Edmunds tries to bring him down during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans running back Dion Lewis (33) is tackled by Buffalo Bills defensive tackle Jordan Philips, top, and defensive end Jerry Hughes during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans kicker Ryan Succop (4) celebrates his field goal with Brett Kern (6) during the first half of an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota (8) scrambles against the Buffalo Bills during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans kicker Ryan Succop (4), with Brett Kern holding, kicks a field goal as Buffalo Bills cornerback Tre'Davious White (27) tries to block it during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans wide receiver Taywan Taylor (13) is unable to catch a pass from quarterback Marcus Mariota, not pictured, during the first half of an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans linebacker Kamalei Correa (44) is held back by head coach Mike Vrabel as he argues with Buffalo Bills offensive tackle Dion Dawkins (73) during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans center Ben Jones right, waits to snap the ball against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans head coach Mike Vrabel, left, talks to line judge Tim Podraza (47) during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans head coach Mike Vrabel, left, talks to line judge Tim Podraza (47) during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans kicker Ryan Succop (4), with Brett Kern holding, kicks a field goal as Buffalo Bills cornerback Tre'Davious White (27) tries to block it during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans wide receiver Taywan Taylor (13) runs with the ball as Buffalo Bills linebacker Tremaine Edmunds tries to bring him down during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans head coach Mike Vrabel, right, talks to head linesman Patrick Turner (13) during the first half of an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota throws a pass against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans kicker Ryan Succop (4) celebrates his field goal with Brett Kern (6) during the first half of an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota (8) stands with teammates between plays against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota looks to hand off the ball against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans center Ben Jones, center right, waits to snap the ball against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota (8) tries to make a pass as Buffalo Bills linebacker Tremaine Edmunds (49) makes the hit during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans head coach Mike Vrabel, right, tries to break up a fight between Titans' linebacker Kamalei Correa (44) and Buffalo Bills offensive tackle Dion Dawkins (73) during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota looks on from the bench during the second half of an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota, top, leaps over Buffalo Bills linebacker Matt Milano during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans cornerback Adoree' Jackson intercepts a pass from Buffalo Bills quarterback Josh Allen, not pictured, during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota looks to pass against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans center Ben Jones right, waits to snap the ball against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans kicker Ryan Succop (4), with Brett Kern holding, kicks a field goal against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. The Bills won 13-12. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota (8) tries to make a pass as Buffalo Bills linebacker Tremaine Edmunds (49) makes the hit during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. Bills' Lorenzo Alexander (57) helps defend on the play. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans wide receiver Nick Williams drops a pass from quarterback Marcus Mariota near the end zone during the second half of an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Buffalo Bills kicker Stephen Hauschka, center, talks to Tennessee Titans cornerback Adoree' Jackson, left, as Titans kicker Ryan Succop looks on during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. The Bills won 13-12. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans quarterback Marcus Mariota, top, leaps over Buffalo Bills linebacker Matt Milano during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Buffalo Bills kicker Stephen Hauschka, center, and holder Corey Bojorquez, left, watch Hauschka's game-winning field goal as Tennessee Titans cornerback Malcolm Butler (21) reacts during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. The Bills won 13-12. (AP Photo/Adrian Kraus)
Buffalo Bills safety Dean Marlowe, right, tackles Tennessee Titans wide receiver Tajae Sharpe during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Buffalo Bills free safety Jordan Poyer (21) applies a tackle on Tennessee Titans running back Dion Lewis (33) during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. The Bills won 13-12. (AP Photo/Adrian Kraus)
Buffalo Bills quarterback Josh Allen (17) dives in for a rushing touchdown against the Tennessee Titans during the first half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans kicker Ryan Succop celebrates after kicking a field goal against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. The Bills won 13-12. (AP Photo/Adrian Kraus)
Tennessee Titans wide receiver Darius Jennings (15) runs for yardage as Buffalo Bills cornerback Taron Johnson (24) tries to bring him down during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota, top, leaps over Buffalo Bills linebacker Matt Milano during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans cornerback Adoree' Jackson intercepts a pass from Buffalo Bills quarterback Josh Allen during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans quarterback Marcus Mariota, left, talks to Buffalo Bills quarterback Josh Allen after an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. The Bills won 13-12. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans quarterback Marcus Mariota (8) stands with teammates between plays against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Buffalo Bills kicker Stephen Hauschka, right, talks to Tennessee Titans punter Brett Kern after an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. The Bills won 13-12. (AP Photo/Adrian Kraus)
Tennessee Titans head coach Mike Vrabel, right, tries to break up a fight between Titans' linebacker Kamalei Correa (44) and Buffalo Bills offensive tackle Dion Dawkins (73) during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans cornerback Adoree' Jackson (25) celebrates his interception on a pass from Buffalo Bills quarterback Josh Allen, not pictured, with defensive back Kendrick Lewis (28) during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota, left, prepares to leap over Buffalo Bills linebacker Matt Milano during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota looks to hand off the ball against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans quarterback Marcus Mariota (8) tries to make a pass as Buffalo Bills linebacker Tremaine Edmunds (49) makes the hit during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans kicker Ryan Succop (4) reacts after kicks a field goal against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota throws a pass against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans cornerback Adoree' Jackson intercepts a pass from Buffalo Bills quarterback Josh Allen, not pictured, during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans kicker Ryan Succop (4), with Brett Kern holding, kicks a field goal against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota looks on from the bench during the second half of an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota, top, leaps over Buffalo Bills linebacker Matt Milano during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans quarterback Marcus Mariota looks to pass against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans linebacker Kamalei Correa (44) is held back by head coach Mike Vrabel as he argues with Buffalo Bills offensive tackle Dion Dawkins (73) during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota, top, leaps over Buffalo Bills linebacker Matt Milano during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans cornerback Adoree' Jackson (25) celebrates his interception on a pass from Buffalo Bills quarterback Josh Allen, not pictured, with defensive back Kendrick Lewis (28) during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans head coach Mike Vrabel talks to reporters after an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. The Bills won 13-12. (AP Photo/Jeffrey T. Barnes)
Tennessee Titans wide receiver Darius Jennings (15) runs for yardage as Buffalo Bills cornerback Taron Johnson (24) tries to bring him down during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota (8) stands with teammates between plays against the Buffalo Bills during the second half of an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota looks on from the bench during the second half of an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
The Tennessee Titans prepare to take on the Buffalo Bills in Week 5 of the 2018 season on Sunday, Oct. 7, 2018 at New Era Field. (Photos: Donn Jones, AP)
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Tennessee Titans quarterback Blaine Gabbert works out prior to an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota works out prior to an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans head coach Mike Vrabel, left, talks to Buffalo Bills head coach Sean McDermott prior to an NFL football game, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota works out prior to an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Tennessee Titans quarterback Marcus Mariota takes the field to work out prior to an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Julio Cortez)
Tennessee Titans quarterback Marcus Mariota (8) talks to referee Tony Corrente (99) prior to an NFL football game against the Buffalo Bills, Sunday, Oct. 7, 2018, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
