NASHVILLE, Tenn. (AP) -- Eli Manning threw for 260 yards and a touchdown, and the New York Giants snapped a seven-game skid with 36-7 victory over the Tennessee Titans Sunday at LP Field.

Tennessee (2-11) lost its seventh straight and for the 11th time in 12 games, marking the franchise's longest skid since losing 11 straight in 1994 as the then-Houston Oilers.

The Giants (4-9) won for the first time since Oct. 5 with two rookies having big games. Odell Beckham Jr. set a team rookie record with his fourth game with 100 yards receiving this season: 11 catches for 130 yards and a TD. Andre Williams ran for a season-high 131 yards, including a 50-yard TD.

Manning and Beckham connected early and often, helping the Giants dominate with a 402-207 edge in total offense. New York's defense also recorded eight QB sacks.

The Titans' loss became even more painful with rookie quarterback Zach Mettenberger hurting his sprained right shoulder in the fourth quarter, and he did not return. Mettenberger said his shoulder hurt after the game, and he will have an MRI exam Monday.

"Obviously, it was a tough day today," Titans coach Ken Whisenhunt said. "It's not fun, but we're working. The only thing is our guys, they're trying, they're working hard, and we'll keep working and come out of it."

The Titans had only four players that started the season at their offensive positions with left tackle Taylor Lewan and right tackle Michael Oher missing their second straight starts because of injuries. When right tackle Byron Stingily went down, Tennessee finished with a tackle signed Tuesday.

The Titans' only points came when Marqueston Huff returned an interception 23 yards for a TD.

Mettenberger completed 14-of-24 passes for 125 yards and an interception before leaving the game early in the fourth quarter. Jake Locker finished out the game, completing 9-of-11 passes for 81 yards and an interception.