Linebacker David Thornton (hip), cornerback Nick Harper (groin) and defensive end Dave Ball (back) will all be doubtful after not practicing Wednesday or Friday. Titans players had Christmas Day off.
Additionally, running back LenDale White did not practice all week because of illness and will be questionable for the game. The Titans also declared three injured players -- defensive end Kyle Vanden Bosch (groin), defensive tackle Albert Haynesworth (knee) and center Kevin Mawae (elbow) -- as out for the game.
Titans coach Jeff Fisher said all three quarterbacks -- Kerry Collins, Vince Young and Chris Simms -- could see action this week.
The Titans are expected to rest plenty of players Sunday because they have already locked up the No. 1 seed in the AFC playoffs; Indianapolis has sewn up the No. 5 spot.
Meanwhile Friday, the NFL fined Pro Bowl cornerback Cortland Finnegan $10,000 for grabbing the open part of the helmet in tackling a player last week in the Titans' win over Pittsburgh. Finnegan was flagged on the play for a personal foul, and it is the second straight week he's been fined by the league.